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MLD and
your child

MLD AND YOUR CHILD

HOW MLD MAY AFFECT YOUR CHILD

Early signs of MLD

The most common early signs of late infantile and juvenile MLD reported by caregivers are motor symptoms and cognitive symptoms. This may appear as an increasing difficulty with moving, talking, swallowing, or eating. The age when children start showing symptoms may vary depending on the form of MLD and the parts of the brain that are affected.

It is important to note that children do not need to have both early motor and cognitive symptoms to be diagnosed with MLD.

Over half of children affected by MLD show symptoms before their third birthday

DIAGNOSING MLD

If you suspect your child may have MLD, talk to their doctor and/or specialist right away. They can take the steps to confirm a diagnosis, or they may refer you to a Qualified Treatment Center (QTC).

If you have a child with an MLD diagnosis, be sure to have a family screening done to identify any other affected siblings.

Early detection of MLD is the key to better outcomes for your child.

IMPORTANT SAFETY INFORMATION

What is LENMELDY?

LENMELDY is a one-time gene therapy developed to treat children with pre-symptomatic late infantile, pre-symptomatic early juvenile and early symptomatic early juvenile, referred to as early-onset, metachromatic leukodystrophy (MLD). MLD is caused by a defect in the arylsulfatase A (ARSA) gene, which causes the body to produce reduced or no ARSA enzyme. LENMELDY is made specifically for each child, using the child’s own blood stem cells, and adding functional copies of the ARSA gene to their cells. This may allow you to produce sufficient ARSA enzyme to stop or slow the progression of MLD symptoms.

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